Scientist/ Research Associate – AI Protein Design

SystImmune Inc. is a clinical-stage bio-pharmaceutical company dedicated to developing innovative treatments for cancer through breakthrough-therapeutic multi-specific antibodies and antibody-drug conjugates (ADCs). With eight assets in ongoing clinical trials and a robust preclinical pipeline, we are seeking a talented Protein Design Scientist or Senior Scientist to join our AI drug design group.

Job Summary:

We are looking for a creative and motivated individual to execute and improve our Computational Protein Design pipeline using data-driven approaches to augment our first-in-class multi-specific biological programs. The ideal candidate will have experience applying computational methods to design novel peptides and proteins, with expertise in structural modeling, prediction, and optimization.

Essential Duties and Responsibilities:

• Execute a computational design pipeline for predicting the properties of peptides, natural ligands, de novo proteins, and antibody-based elements via data-driven approach
• Drive assay validation, tech transfer, and development initiatives to maintain industry standards; Contribute within the computational protein design group to operate yeast display-based protein discovery platforms
• Design new macromolecular therapeutics using structural and sequence analysis, and employ these in silico predictions to iteratively guide the lead development process
• Analyze, interpret, document, and present data to the scientific and leadership team
• Collaborate with our Antibody Discovery, Protein Engineering, and Immuno-oncology teams to contribute to the company's vision

Qualifications:

• PhD (or equivalent) in bioengineering, biophysics, biochemistry, molecular biology, cell biology, or a related field
• 8+ years of experience using yeast libraries to generate protein binding or therapeutic antibodies required
• Experience with relevant macromolecular modeling software (e.g., AlphaFold, RoseTTAFold, RFdiffusion, ProteinMPNN, Gromacs, MOE, Schrödinger)
• Expertise in screening and ranking of antibodies (ELISA, multi-parametric flow cytometry, BLI/OCTET)
• Proven contribution to therapeutic antibody development and selection is desirable; design and validation of novel biologically relevant antibodies are highly desirable

Compensation and Benefits:

The hiring pay range for this position is $80,000 - $180,000 per year based on skills, education, and experience relevant to the role.

SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Redmond, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials, SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discovery or IND-enabling stages, representing cutting-edge biologics development.  

We offer an opportunity for you to learn and grow while making significant contributions to the company’s success. SystImmune offers a comprehensive benefits package.

SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.