Director Commercial Strategy, Iza-Bren

This role will report to the Executive Director, Commercial Strategy.

As the Director Commercial Strategy, Iza-Bren, you will be responsible for development, implementation and management of commercialization strategy for iza-bren, a first-in-class EGFR-HER3 bi-specific antibody drug conjugate being developed under a collaboration agreement with BMS. This role will drive cross-functional alignment across commercial, clinical, regulatory, alliance management functions within SystImmune and is critical in ensuring SystImmune’s vision for Iza-Bren is represented throughout all strategic and operational discussions with BMS.

This is an ideal role for a hands-on commercial leader with expertise in market analysis, forecasting, competitive intelligence, and cross-functional execution in oncology.

Key Responsibilities: 

1. Commercial Execution for Izalontamab-Brengitecan

• Lead the development and execution of the commercialization strategy for Iza-Bren, ensuring alignment across SystImmune and alliance partner BMS.
• Own day-to-day commercial planning, including target product profile (TPP) refinement, competitive positioning, and market readiness activities.
• Work closely with clinical development teams (internal and alliance) to incorporate commercial insights into trial design and lifecycle planning.
• Co-create and support execution of medical advisory boards and thought leader engagements (TLEs) to ensure external perspectives inform strategy.

2. Market & Competitive Insights, Forecasting, and Commercial Analytics

• Conduct market research and landscape assessments to refine patient segmentation, uptake drivers, and barriers.
• Develop a competitive intelligence framework, monitoring key ADC competitors and identifying implications for brand strategy.
• Work closely with Finance and Business Development to develop and maintain revenue forecasts, ensuring alignment across internal and Alliance teams.
• Assess pricing and market dynamics, leveraging epidemiology data, analogs, and external insights to refine commercialization plans.
• Map out and prioritize key performance indicators (KPIs) for market readiness and stakeholder engagement, ensuring SystImmune’s strategic priorities are represented.

3. Cross-Functional & Alliance Collaboration for Market Preparation

• Work closely with Medical Affairs, Regulatory, Market Access, and other key functions (both internal and Alliance) to align commercialization efforts.
• Ensure SystImmune’s vision is recognized in all Alliance discussions and decision-making across commercial, clinical, and medical affairs teams.
• Support early-stage launch readiness planning, including defining key priorities for stakeholder engagement and market preparation efforts.
• Partner with Alliance teams to ensure cohesive strategic messaging, commercial positioning, and cross-functional coordination.

Qualifications:

• Advanced degree (MBA, PharmD, PhD, or equivalent) in business, life sciences, or a related field.
• 7+ years of related experience in biotech/pharmaceutical and/or life sciences consulting roles, including commercial strategy, forecasting, market research, brand planning, or portfolio management.
• Proven ability to collaborate across multiple functions, including clinical development, regulatory, medical affairs, finance, and market access, to align on commercialization strategies.
• Strong ability to analyze complex data and translate insights into strategic recommendations.
• Excellent communication and presentation skills across a variety of organization levels and functions including senior executives.
• Ability to influence and build effective relationships both within the organization and externally with alliance partners to drive projects and tasks towards completion.
• Prior experience in ADCs is a plus but not required; experience in oncology and/or specialty pharmaceuticals preferred.
• Experience working in an alliance or partnership setting is a plus.

The hiring pay range for this position is $180,000 - $250,000 per year based on skills, education, and experience relevant to the role.

SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Redmond, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs).

SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials, SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discovery or IND-enabling stages, representing cutting-edge biologics development.

We offer an opportunity for you to learn and grow while making significant contributions to the company’s success. SystImmune offers a comprehensive benefits package.

SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.