Senior Research Associate/Associate Scientist, Protein Engineering

Redmond, WA

Full Time

Protein Engineering

Experienced

SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Redmond, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials. SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company's success.

We are seeking a highly motivated Senior Research Associate or Associate Scientist to join our Protein Engineering team. This role is ideal for a protein biochemistry-focused scientist who thrives in a fast-paced, collaborative environment and is passionate about therapeutic antibody development.

The successful candidate will work closely with experienced scientists to execute and optimize protein purification workflows, support transient mammalian expression, and perform analytical characterization and developability assessments. This individual will play a critical role in delivering high-quality protein reagents that directly enable discovery and preclinical development. Over time, this role is expected to grow toward greater scientific independence and technical ownership.

Key Responsibilities

Execute daily protein purification workflows using FPLC ÄKTA systems (affinity, ion exchange, and size exclusion chromatography).
Develop and support scalable, robust purification processes for antibody and recombinant protein constructs.
Operate and maintain FPLC and HPLC/UPLC systems with high efficiency and data integrity.
Perform analytical characterization of purified proteins, including SEC-based purity and aggregation assessments.
Support routine transient transfections of CHO cells for mammalian protein expression.
Assist in cell culture maintenance and harvest processing for downstream purification.
Conduct biochemical and biophysical characterization to support developability assessments.
Maintain detailed experimental records in electronic lab notebooks.
Collaborate closely with research scientists to prioritize workflows, troubleshoot challenges, and meet program timelines.
Contribute to continuous improvement of purification and analytical workflows to enhance throughput and quality.

Qualifications

Bachelor’s or Master’s degree in Biochemistry, Protein Sciences, Molecular Biology, or a related field.
2–5+ years of hands-on industry or academic laboratory experience in protein purification.
Strong background in protein biochemistry and chromatographic techniques.
Demonstrated experience with FPLC ÄKTA purification systems.
Experience operating HPLC/UPLC systems, specifically size exclusion chromatography (SEC).
Familiarity with affinity, ion exchange, and size exclusion chromatography methods.
Basic understanding of mammalian cell culture techniques.
Strong organizational skills and ability to manage multiple priorities in a dynamic environment.

Preferred

Previous experience working with therapeutic antibodies or antibody fragments.
Experience with CHO cell culture and transient transfection workflows.
Experience with mammalian expression systems.
Exposure to biophysical characterization techniques relevant to protein developability.

Compensation and Benefits:
The expected base salary range for this position is $60,000 - $85,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate’s level qualifications, experience, and skills.
While most offers typically fall within the low to mid-point of the range, we may extend an offer toward the higher end for exceptional candidates whose background and expertise exceeds the requirements of the role.

SystImmune is a leading and well-funded biotech company with a bright future. We offer an opportunity for you to learn and grow while making significant contributions to the company’s success. SystImmune offers a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE.

We offer an opportunity for you to learn and grow while making significant contributions to the company’s success.

SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.

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This role requires daily hands-on protein purification using ÄKTA FPLC systems. Describe the last purification you personally ran. Include:

• Type of protein purified
• Affinity resin used (example: Protein A, Ni-NTA, etc.)
• SEC column used and what you were evaluating (aggregation, purity, MW, etc.)
• One parameter you adjusted during the run (flow rate, CVs, buffer, injection volume, etc.)*

You purify an antibody using Protein A affinity chromatography followed by SEC and see a large high-molecular weight peak in SEC. What are 2 likely causes and what is one change you would make in your next purification to reduce it?

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Senior Research Associate/Associate Scientist, Protein Engineering

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